Safety of Biologics Therapy by Brian A. Baldo

Author:Brian A. Baldo
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Other Reported Adverse Events to Abatacept

Adverse skin reactions to abatacept appear to be rare but there are a number of cases of paradoxical psoriasiform eruptions to the agent. A meta-analysis of trials in which rheumatoid arthritis patients received abatacept as monotherapy (1332 patients), or together with other antirheumatic drugs (1945 patients), revealed 4 (0.3 %), and 13 (0.67 %) cases of psoriasis, respectively. A case of erythema elevatum diutinium has been reported in a juvenile idiopathic arthritis patient treated with abatacept.

The recent interesting observations that abatacept produced partial or complete remissions of proteinuria in five patients with focal segmental glomerulosclerosis (FSGS), that four of the patients had recurrent FSGS after transplantation, and patients had proteinuria with B7-1 immunostaining of podocytes in kidney biopsy specimens, suggests that B7-1 may be a useful marker for the treatment of some glomerulopathies.

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